About us

DepartmentPeking University Third Hospital (PUTH)
Address49 Huayuan North Road, Haidian District, Beijing 100191, China.
ResearchGenome Medicine, Genomics and Epigenomics, Bioinformatics.

Our team is dedicated to complex disease studies, focusing on development of biological databases by large-scale data integration and data mining, and development of bioinformatics tools and web servers to facilitate researchers to analyze the epigenomic, genetic and regulatory data of complex diseases. We mainly focus on interpretation of genetic variations and epigenetic regulations in human cancers and psychiatric disorders. Our published disease related databases include a functional variants database involved in post-transcriptional regulation mediated by RNA-binding (RBP-Var, 2016), a platform for linking regulatory de novo mutations to developmental epigenetics and diseases (EpiDenovo, 2018), a platform for decoding regulatory somatic mutations in human cancers (OncoBase, 2019) and an integrated database and analysis platform for oncogenic driver variants in human cancers (OncoVar, 2021). Our published bioinformatics tools include a Bayesian framework to identify methylcytosines from high-throughput bisulfite sequencing data (Bycom, 2014), estimating genome-wide single-base methylation level from MB-seq data combined with RRBS data (MBRidge, 2015), a deep learning algorithm for identifying posttranscriptionally impaired SNVs (PIVar, 2020) and an ensemble learning method for identifying driver mutations in personal cancer genomes (AI-Driver, 2020).

CircleBase team

Name E-mail
Xiaolu Zhaoxiaolu_zhao@163.com
Leisheng Shislsbioinfo@126.com
Mingkun Lilimk@big.ac.cn
Fengbiao Maomaofengbiao@126.com


We hope you enjoy this database as much as we do and please feel free to email us with any suggestions or questions.

For bug report, email to slsbioinfo@126.com.

For data source recommendation, email to maofengbiao@126.com.